Beta-Adrenergic Blockers’ Supportive and Adverse Role in Hypertension: A Review of Three Generations

ABSTRACT Hypertension causes significant mortality and morbidity around the world. The β-adrenergic blockers are one of most commonly prescribed hypertension medications. Several with different pharmacological qualities have been developed, which may be grouped into three generations based on differences in properties. In this narrative review, we addressed evidence-based literature about role various types β-blockers related adverse drug reactions (ADRs) hypertension. PubMed, Scopus, Google Scholar, MEDLINE used for articles search. title was examined first, followed by abstract, then entire study. We concluded that first-generation non-selective as antihypertensive however, not recommended diabetic, asthmatic, chronic obstructive pulmonary disease patients. second-generation β1 receptor-selective effective option treatment hypertension, a lower risk effects associated antagonism β2-receptor. Third-generation showed improved patients compared to previous two generations. This class (labetalol, carvedilol, nebivolol) has vasodilatory abilities an extra beneficial influence fewer ADRs. However, effectiveness benefit first‐line therapy is still controversial. As result, further accurate screenings, well large randomized control clinical trials (RCTs), needed investigate all Keywords: Hypertension; Beta-Adrenergic Blockers; Blood Pressure; Literature Review.